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Os sintomas persistentes da síndrome pós-COVID-19 acarretam impactos negativos na saúde, qualidade de vida e produtividade. O objetivo deste trabalho foi descrever os sintomas persistentes da síndrome pós-COVID-19, principalmente neurológicos, e as repercussões cognitivas, emocionais, motoras, de qualidade de vida e de custos indiretos, 12 meses após a infecção. Pacientes com primeiros sintomas entre janeiro e junho de 2021 evoluíram com síndrome pós-COVID-19 e procuraram atendimento na unidade da Rede SARAH de Hospitais de Reabilitação em Fortaleza, Ceará, Brasil. As informações foram obtidas no início do acompanhamento e por entrevista telefônica após 12 meses da infecção. Participaram do estudo 58 pessoas, com idade média de 52,8 anos (±10,5) e 60% permaneceram em UTI. Os sintomas mais frequentes na admissão foram: fadiga (64%), artralgia (51%) e dispneia (47%); e após 12 meses: fadiga (46%) e alteração de memória (39%). Foram identificadas alterações nas escalas/testes funcionais: PCFS, MoCA, HAD, FSS, SF-36, TLS5x, Timed up and go, caminhada de 6 minutos e preensão manual. Os custos indiretos totais foram de USD 227.821,00, com 11.653 dias de absenteísmo; 32% dos pacientes não voltaram a trabalhar. Melhores resultados de TLS5x e SF-36, nas dimensões capacidade funcional, aspecto físico, vitalidade e dor, demonstraram associação com retorno laboral (p ≤ 0,05). Os sintomas persistentes mais frequentes foram: fadiga, artralgia, dispneia, ansiedade e depressão, com repercussões negativas na funcionalidade cognitiva, emocional, motora e qualidade de vida. Esses sintomas perduraram por mais de um ano, principalmente fadiga e alteração de memória, sendo esta última mais relatada tardiamente. Houve dificuldade importante de retorno laboral e custos indiretos de USD 4.847,25 por pessoa/ano.

The persistent symptoms of post-COVID-19 syndrome negatively impact health, quality of life, and productivity. This study aimed to describe the persistent symptoms of post-COVID-19 syndrome (especially neurological ones) and their 12-month post-infection cognitive, emotional, motor, quality of life, and indirect cost repercussions. Patients showing the first symptoms of COVID-19 from January to June 2021 who developed post-COVID-19 syndrome and sought care at the Fortaleza Unit (Ceará, Brazil) of the SARAH Network of Rehabilitation Hospitals were included in this study. Information was obtained at the baseline follow-up and by telephone interview 12 months post-infection. In total, 58 people participated in this study with an average age of 52.8±10.5 years, of which 60% required an ICU. The most frequent symptoms on admission included fatigue (64%), arthralgia (51%), and dyspnea (47%), whereas, after 12 months, fatigue (46%) and memory impairment (39%). The following scales/functional tests showed alterations: PCFS, MoCA, HAD, FSS, SF-36, TLS5x, timed up and go, 6-minute walk, and handgrip. Indirect costs totaled USD 227,821.00, with 11,653 days of absenteeism. Moreover, 32% of patients were unable to return to work. Better TLS5x and higher SF-36 scores in the functional capacity, physical functioning, vitality, and pain dimensions were associated with return to work (p ≤ 0.05). The most frequent persistent symptoms referred to fatigue, arthralgia, dyspnea, anxiety, and depression, which negatively affected cognitive, emotional, and motor function and quality of life. These symptoms lasted for over a year, especially fatigue and memory alteration, the latter of which being the most reported after COVID-19 infections. Results also show a significant difficulty returning to work and indirect costs of USD 4,847.25 per person/year.

Síntomas persistentes del síndrome post-COVID-19 provocan impactos negativos en la salud, calidad de vida y productividad. El objetivo fue describir los síntomas persistentes del síndrome post-COVID-19, sobre todo neurológicos, y las repercusiones cognitivas, emocionales, motoras, de calidad de vida y los costos indirectos, 12 meses tras la infección. Pacientes que tuvieron los primeros síntomas entre enero y junio de 2021, desarrollaron síndrome post-COVID-19 y buscaron atención en la unidad de la Red SARAH de Hospitales de Rehabilitación en Fortaleza, Ceará, Brasil. Las informaciones se obtuvieron al inicio del seguimiento y por entrevista telefónica 12 meses tras la infección. Participaron 58 personas, con edad de 52,8±10,5 años y el 60% permaneció en la UTI. Los síntomas más frecuentes al ingreso fueron: fatiga (64%), artralgia (51%) y disnea (47%); tras 12 meses fueron: fatiga (46%) y alteración de memoria (39%). Se identificaron alteraciones en las escalas/testes funcionales: PCFS, MoCA, HAD, FSS, SF-36, TLS5x, timed up and go, caminar por 6 minutos y prensión manual. Los costos indirectos totales fueron USD 227.821,00, con 11.653 días de absentismo. El 32% de los pacientes no volvió a trabajar. Mejor TLS5x y SF-36 en las dimensiones capacidad funcional, aspecto físico, vitalidad y dolor demostraron una asociación con el retorno al trabajo (p ≤ 0,05). Los síntomas persistentes más frecuentes fueron fatiga, artralgia, disnea, ansiedad y depresión, con repercusiones negativas en la funcionalidad cognitiva, emocional, motora y calidad de vida. Estos síntomas continuaron por más de un año, sobre todo la fatiga y la alteración de la memoria, siendo esta última reportada con más frecuencia tardíamente. Hubo una dificultad importante en el retorno al trabajo y costos indirectos de USD 4.847,25 persona/año.

https://doi.org/10.1590/0102-311xpt026623

Fatores associados à osteoporose em pessoas idosas em um centro de referência
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Colares, Thomaz de Figueiredo Braga

; Vasconcelos, Ana Carolina Bromenschenkel

; Maia, Luciana Colares

; Caldeira, Antônio Prates

; Rossi-Barbosa, Luiza Augusta Rosa

PsychTech & Health Journal

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Dez 2023, Volume 7 Nº 2 Páginas 63 - 72

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract This study aimed to estimate the prevalence of osteoporosis among elderly individuals receiving treatment at a designated reference center and to identify associated factors. The research employed a cross-sectional, analytical design, involving the collection of data from medical records and interviews with elderly individuals undergoing treatment at the Reference Center for Health Care for the Elderly (CRASI), specifically those who underwent bone densitometry examinations in the years 2017 and 2018. Bivariate analysis was conducted to explore the association between osteoporosis and various group characteristics, including sociodemographic profile, Body Mass Index (BMI), lifestyle habits, care, and health conditions. Variables showing an association up to a significance level of 20% (p ≤ .20) were collectively evaluated through Poisson multiple regression with a robust estimator. Only variables demonstrating a significance level of up to 5% were admitted to the final model. The prevalence of osteoporosis was found to be 48.5%. In the final model, the following variables were identified as being associated: female sex (RP = 1.88; 95%CI: 1.36 - 2.60), age over 80 years old (RP = 1.55; 95%CI: 1.29 - 1.85), BMI less than 22 (RP = 1.23; 95%CI: 1.02 - 1.49), and as a protective factor, BMI above 27 (RP = .52; 95%CI: .41 - .67). In conclusion, a high prevalence of osteoporosis was observed, with associations identified between osteoporosis and modifiable factors such as low weight, as well as non-modifiable factors including sex and age. No significant associations were discerned with variables related to lifestyle habits.

Resumo Este estudo objetivou estimar a prevalência de osteoporose em idosos atendidos em um centro de referência e identificar fatores associados. Trata-se de um estudo transversal, analítico, com coleta de dados em prontuários médicos e entrevistas aos idosos atendidos no Centro de Referência em Assistência à Saúde dos Idosos (CRASI), e que realizaram exame de densitometria óssea nos anos de 2017 e 2018. Utilizou-se análise bivariada para investigar a associação entre osteoporose e características do grupo: perfil sociodemográfico, Índice de Massa Corporal (IMC), hábitos de vida, cuidados e condições de saúde. As variáveis com associação até o nível de 20% (p ≤ .20) foram avaliadas de forma conjunta por regressão múltipla de Poisson com estimador robusto, admitindo-se para o modelo final apenas as variáveis com nível de significância de até 5%. A prevalência de osteoporose foi de 48.5%. No modelo final ficaram associadas as variáveis: sexo feminino (RP = 1.88; IC95%: 1.36 - 2.60), idade acima de 80 anos (RP = 1.55; IC95%: 1.29 - 1.85), IMC menor que 22 (RP = 1.23; IC95%: 1.02 - 1.49) e como protetor IMC acima de 27 (RP = .52; IC95%: .41 - .67). Concluindo,verificou-se alta prevalência de osteoporose e associação como fator modificável o baixo peso e outros não modificáveis: sexo e idade. Não foram identificadas associações com variáveis relacionadas aos hábitos de vida.

https://doi.org/10.26580/pthj.art67-2024

Os limites da curatela e o consentimento livre e esclarecido da pessoa com deficiência
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MEIRELLES, JUSSARA MARIA LEAL DE

; VASCONCELOS, ANA PAULA

Estudos Avançados

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Dez 2023, Volume 37 Nº 109 Páginas 145 - 158

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO O presente trabalho aborda a possibilidade de consentimento substitutivo no âmbito da saúde em casos de pessoas em situação de curatela, para averiguar se seria permitido ao representante legal da pessoa com deficiência decidir também sobre aspectos existenciais. Para tanto, apresenta-se uma análise do consentimento livre e esclarecido como materialização do respeito à autonomia do paciente, e dos seus requisitos de validade, especialmente no que se refere à capacidade. São analisadas, também, as alterações promovidas pelo Estatuto da Pessoa com Deficiência para promover a inclusão e a autonomia da pessoa com deficiência, especialmente no que se refere aos limites da curatela. curatela existenciais tanto apresentase apresenta paciente validade capacidade analisadas

ABSTRACT The present work will address the possibility of substitutive health consent in cases of people in situation of guardianship, to ascertain whether the legal representative of the person with disabilities would be allowed to decide also on existential aspects. Therefore, an analysis of free and informed consent will be made as materialization of respect for the patient’s autonomy, and their validity requirements, especially regarding capacity. The changes promoted by the Statute of Persons with Disabilities to promote the inclusion and autonomy of persons with disabilities, especially regarding the limits of guardianship, will also be analyzed. guardianship aspects Therefore patients patient s requirements capacity analyzed

https://doi.org/10.1590/s0103-4014.2023.37109.010

Acinic cell carcinoma of the oral and maxillofacial region: an international multicenter study
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KIRSCHNICK, Laura Borges

; SILVEIRA, Felipe Martins

; SCHUCH, Lauren Frenzel

; VASCONCELOS, Ana Carolina Uchoa

; GOMES, Ana Paula

; SANTOS, Jean Nunes dos

; SANTANA, Dandara Andrade

; FONSECA, Felipe Paiva

; MESQUITA, Ricardo Alves

; MENDONÇA, Elismauro Francisco de

; SOUSA-NETO, Sebastião Silvério

; PONTES, Hélder Antônio Rebelo

; ROBINSON, Liam

; HEERDEN, Willie van

; CARLOS-BREGNI, Román

; TAGER, Elena María José Román

; SILVA, Luan César da

; ZANELLA, Virgílio Gonzales

; RIVERO, Luis Fernando

; BITTENCOURT, Raquel

; MARTINS, Marco Antonio Trevizani

; LOPES, Márcio Ajudarte

; WAGNER, Vivian Petersen

; VARGAS, Pablo Agustin

; MARTINS, Manoela Domingues

Brazilian Oral Research

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2023, Volume 37 elocation e050

Resumo: En | Texto: En | PDF: En

Abstract The aim of this study was to describe the prevalence, clinicopathological, and prognostic features of acinic cell carcinoma (AciCC) of the oral and maxillofacial region. AciCC cases were retrospectively retrieved from 11 pathology centers of three different countries. Medical records were examined to extract demographic, clinical, pathologic, and follow-up information. A total of 75 cases were included. Females (65.33%) with a mean age of 45.51 years were mostly affected. The lesions usually presented as an asymptomatic (64.28%) nodule (95.66%) in the parotid gland (70.68%). The association of two histopathological patterns was the most common finding (48.93%) and the tumors presented mainly conventional histopathological grades (86.11%). Surgical treatment was performed in the majority of the cases (59.19%). Local recurrence was observed in 20% of the informed cases, regional metastasis in 30.43%, and distant metastasis in 12.50%. The statistical analysis showed that the cases with a solid histopathological pattern (p=0.01), high-grade transformation (p=0.008), recurrence (p=0.007), and regional metastasis (p=0.03) were associated with poor survival. In conclusion, high histopathological transformation, presence of nodal metastasis, and recurrence were prognostic factors for AciCC of the oral and maxillofacial region.

https://doi.org/10.1590/1807-3107bor-2023.vol37.0050

Dynamic response of piled structures including pile-soil-pile interaction pilesoilpile pile soil
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Oliveira, Amanda

; Vasconcelos, Ana Carolina Azevedo

; Labaki, Josué

Latin American Journal of Solids and Structures

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2023, Volume 20 Nº 6 elocation e491

Resumo: En | Texto: En | PDF: En

Abstract This article presents a numerical model and analyses of the dynamic response of structures supported by groups of piles. The model uses a finite element discretization to represent arbitrarily-shaped structures, and a coupled finite-boundary element scheme to represent the embedded pile group. This scheme properly takes into account the energy transferred from the structure to the piles and between piles through the soil, so that the effect of dynamic pile-soil-pile interaction in the response of the structure can be studied. The model is used to analyze the dynamic response of a wind turbine tower and foundation blocks of various designs. The results show that some common design approximations may result in considerable misrepresentation of the response of these structures. The model is also used to analyze cases in which the only source of excitation to a structure comes through the soil from neighboring structures. The results showed that the farther the structure is from the source of vibration, the lower its amplitude of vibration and that the taller the structure, the lower its resonant frequencies. These analyses are only possible with models like the one presented in this article, which are able to describe the energy exchanged through the soil by the piles in a group. arbitrarilyshaped arbitrarily shaped finiteboundary boundary group pilesoilpile studied designs frequencies

https://doi.org/10.1590/1679-78257514

Editorial
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Vasconcelos, Ana Cláudia Leal

; Pessoa, Manuella Castelo Branco

Laboreal

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Dez 2022, Volume 18 Nº 2 elocation e19564

Resumo: Pt | Texto: Pt | PDF: Pt

https://doi.org/10.4000/laboreal.19564

Aesthetic assessment of breast reconstruction in the eyes of plastic surgeons versus nonplastic physicians
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Siqueira, Hianga Fayssa Fernandes

; Teixeira, Jorge

; Lessa Filho, Reginaldo

; Brito, Erika de Abreu Costa

; Lima, Marcela

; Moura, Alex Rodrigues

; Figueiredo, Tarcizo

; Oliveira, Thiago

; Vasconcelos, Ana Alice Santana

; Lima, Carlos Anselmo

Revista da Associação Médica Brasileira

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Jan 2022, Volume 68 Nº 1 Páginas 13 - 18

Resumo: En | Texto: En | PDF: En

SUMMARY OBJECTIVE: The aim of this study was to evaluate the perception of the aesthetic result of breast reconstruction surgery from the perspective of plastic surgeons compared with physicians who are not specialists in plastic surgery. METHODS: Twenty patients who underwent breast reconstruction after mastectomy had their aesthetic results evaluated by 16 plastic surgeons and 16 nonplastic physicians, yielding a total of 620 ratings (320 ratings from plastic surgeons and 320 ratings from other specialists). For all analyses, the level of rejection adopted for the null hypothesis was 5% (p-value <0.05). RESULTS: Significant differences were observed between the two groups. On average, medical professionals who specialized in plastic surgery always obtained higher scores than other physicians. However, no significant differences were found in the assessment of the aesthetic outcome of breast reconstruction according to the sex of the rating medical professional for any of the assessments considered in this study. A strong positive linear correlation between the time since training in the medical specialty of plastic surgery (r=0.750, p=0.001) and the mean aesthetic outcome score was observed in this study. CONCLUSION: Plastic surgeons assessed the aesthetic results of breast reconstruction more positively than nonplastic physicians.

https://doi.org/10.1590/1806-9282.20210110

Recadastramento da população residente em Foz do Iguaçu, Brasil, em atendimento à Política de Atenção Primária à Saúde
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Gomes, Marília Miranda Forte

; Souza Cruz, Rebeca Carmo de

; Vasconcelos, Ana Maria Nogales

; Izuka, Adriana

; Bom, Carmensita Gaievski

; Parra da Luz, Larissa Djanilda

; Uchimura, Kátia Yumi

; Terabe, Sandro

; Cortez-Escalante, Juan José

; Almirón, Maria

Revista Panamericana de Salud Pública

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2022, Volume 46 elocation e158

Resumo: Es En Pt | Texto: Es En Pt | PDF: Es | PDF: En | PDF: Pt

RESUMEN Objetivo. Presentar la experiencia y los resultados de la reinscripción de la población residente en Foz do Iguaçu, un municipio fronterizo ubicado en el estado de Paraná (Brasil), en cumplimiento de las directrices de la Política de atención primaria de salud y su nuevo modelo de financiamiento (Programa Previne Brasil). Métodos. Utilizando una estrategia de barrido (muestreo de conveniencia) para la recolección de datos, se visitaron 52 263 hogares y se realizaron 22 710 entrevistas entre septiembre y noviembre de 2019. Las entrevistas fueron presenciales y estuvieron a cargo de 54 trabajadores comunitarios de salud. Se recopilaron datos sobre el hogar (régimen de propiedad de la vivienda, ubicación en una zona urbana o rural, tipo de vivienda, material de construcción, disponibilidad de redes de energía eléctrica y alcantarillado, abastecimiento de agua y eliminación de desechos) e información sobre la composición demográfica y la salud de los residentes. Resultados. La reinscripción reveló que los residentes eran propietarios de sus viviendas y que estas se encontraban ubicadas en zonas urbanas, estaban bien construidas y tenían servicios de energía eléctrica, abastecimiento de agua y recolección de basura. El 52,8% de la población registrada correspondió a mujeres, el 62,5% tenía entre 15 y 59 años y el 60,0% declaró que era de raza blanca. El 90,0% de los entrevistados mayores de 15 años había terminado la escuela primaria. La ocupación principal era “persona asalariada con carnet de trabajo”. Además, el 18,6% de los entrevistados indicó que tenía hipertensión y el 7,0%, diabetes. Conclusiones. La reinscripción aportó información relevante para apoyar la planificación de la atención primaria de salud , así como las iniciativas en materia de asistencia social, trabajo y vivienda; también fue fundamental para definir las estrategias de atención de salud en ese municipio fronterizo durante la pandemia de COVID-19.

ABSTRACT Objective. To present the experience and results of the reregistration of residents in Foz do Iguaçu, a border town located in the state of Paraná, Brazil, to meet the guidelines of the national Primary Health Care (PHC) Policy and its new financing model (Programa Previne Brasil). Method. A scanning strategy (convenience sample) was used for data collection, with 52 263 households visited and 22 710 interviews conducted from September to November 2019. The interviews were conducted face-to-face by 54 community health workers. Data were collected on the household (ownership status, urban or rural location, type of household, construction material, availability of electrical and sewage networks, water supply and waste disposal). Demographic and health information on the residents was also collected. Results. The reregistration process revealed that most residents were home owners and lived in well-constructed homes, located mostly in urban areas, served by electricity, with access to water supply and garbage collection. Of the reregistered population, 52.8% were women, 62.5% were aged between 15 and 59 years and 60.0% declared themselves white. Among respondents aged 15 or over, 90.0% had completed elementary school. The main occupation was “formal salaried job”. Additionally, 18.6% of the interviewees declared themselves to be hypertensive and 7.0%, diabetic. Conclusions. The reregistration process uncovered relevant information to support both PHC planning as well as social assistance, work and housing initiatives; it was also fundamental to define health care strategies in this border town during the COVID-19 pandemic.

RESUMO Objetivo. Apresentar a experiência e os resultados do recadastramento da população residente em Foz do Iguaçu, um município de fronteira localizado no estado do Paraná, Brasil, para atender às diretrizes da Política de Atenção Primária à Saúde (APS) e ao seu novo modelo de financiamento pelo Programa Previne Brasil. Métodos. Utilizando uma estratégia de varredura (amostra de conveniência) para coleta de dados, foram visitados 52 263 domicílios e realizadas 22 710 entrevistas de setembro a novembro de 2019. As entrevistas foram realizadas pessoalmente por 54 agentes comunitários de saúde. Foram coletados dados sobre o domicílio (status de posse da moradia, localização urbana ou rural, tipo de domicílio, material da construção, disponibilidade de rede elétrica e de esgoto, abastecimento de água e destino do lixo) e informações demográficas e de saúde dos moradores. Resultados. O recadastramento revelou que os domicílios eram predominantemente casas próprias, em área urbana, bem edificados e servidos por energia elétrica, rede geral de água e coleta de lixo. Sobre a população recadastrada, 52,8% eram mulheres, 62,5% tinham idade de 15 a 59 anos e 60,0% se autodeclararam brancos. Entre os entrevistados com 15 anos ou mais, 90,0% tinham completado o ensino fundamental. A principal ocupação foi “assalariado com carteira de trabalho”. Ainda, 18,6% dos entrevistados se autodeclararam hipertensos e 7,0%, diabéticos. Conclusões. O recadastramento trouxe informações relevantes para subsidiar o planejamento da APS, assim como iniciativas de assistência social, trabalho e habitação; também foi fundamental para definir estratégias de atenção à saúde nesse município de fronteira durante a pandemia de COVID-19.

https://doi.org/10.26633/rpsp.2022.158

Road traffic injuries and deaths and the achievement of UN Sustainable Development Goals in Brazil: results from the Global Burden of Disease Study, 1990 to 2019
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Malta, Deborah Carvalho

; Morais Neto, Otaliba Libânio de

; Cardoso, Laís Santos de Magalhães

; Veloso, Guilherme Augusto

; Andrade, Fabiana Martins Dias de

; Vasconcelos, Ana Maria Nogales

; Lima, Cheila Marina de

; Ribeiro, Antonio Luiz Pinho

; Naghavi, Mohsen

Revista da Sociedade Brasileira de Medicina Tropical

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2022, Volume 55 Supl. 1 elocation e0261-2021

Resumo: En | Texto: En | PDF: En

Abstract INTRODUCTION: Brazil ranks 5th in the number of deaths due to road injuries. This study aimed to analyze mortality and disabilities resulting from road injuries in Brazil, and to assess the Sustainable Development Goals (SDG) target of reducing deaths due to road injuries by 50% by 2030. METHODS: This descriptive and exploratory study used the estimates from the Global Burden of Disease 2019: indicators of mortality, premature deaths, and disabilities according to sex, age group, and type of transport for 1990, 2015, and 2019. Time trends in mortality rates from 1990 to 2019 were assessed, and a projection for 2030 was calculated, applying a linear regression model. RESULTS: Deaths due to road injuries were 44,236 in 1990, and 44,529 in 2019, representing a 43% reduction in mortality rates. The highest rates were in the North, Northeast, and Midwest regions of Brazil, in males and young adults. A 77% reduction was observed in mortality rates for pedestrians and an increase of 53% for motorcyclists and of 54% for cyclists during the period. In terms of motorcycle road injuries, the mortality rate for men increased from 7.3/100,000 (1990) to 11.7/100,000 inhabitants (2019). The rates of premature deaths and disabilities were also higher for men when compared to women. Amputations, fractures, spinal cord injuries, and head trauma were the main types of road injuries. The projections for 2030 show that Brazil might not reach the SDG target. CONCLUSIONS: Despite the decline in mortality rates, the 2030 Agenda’s target might not be achieved.

https://doi.org/10.1590/0037-8682-0261-2021

10.

Excess Mortality due to natural causes among whites and blacks during the COVID-19 pandemic in Brazil
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Teixeira, Renato Azeredo

; Vasconcelos, Ana Maria Nogales

; Torens, Ana

; França, Elisabeth Barboza

; Ishitani, Lenice

; Bierrenbach, Ana Luiza

; Abreu, Daisy Maria Xavier de

; Marinho, Fátima

Revista da Sociedade Brasileira de Medicina Tropical

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2022, Volume 55 Supl. 1 elocation e0283-2021

Resumo: En | Texto: En | PDF: En

Abstract INTRODUCTION: Excess Mortality by all causes considers deaths directly related to COVID-19 and those attributed to conditions caused by the pandemic. When stratified by social dimensions, such as race/color, it allows for the evaluation of more vulnerable populations. The study estimated the excess mortality by natural causes, separating the white and black populations in 2020. METHODS Public civil registration data on deaths observed in 2020, corrected for under registration, were used. The expected number of deaths was estimated based on the mortality rates observed in 2019, applied to the estimated population in 2020. The difference between the values expected and observed and the proportion of excess was considered the excess mortality. RESULTS: The present study found an excess of 270,321 deaths (22.2% above the expected) in 2020. Every state of Brazil reported deaths above the corresponding expected figure. The excess was higher for men (25.2%) than for women (19.0%). Blacks showed an excess of 27.8%, as compared to whites at 17.6%. In both sexes and all age groups, excess was higher in the black population, especially in the South, Southeast, and Midwest regions. São Paulo, the largest in population number, had twice as much excess death in the black population (25.1%) than in the white population (11.5%). CONCLUSIONS: The present study showed racial disparities in excess mortality during the COVID-19 pandemic in Brazil. The higher excess found for the black suggests an intrinsic relationship with the socioeconomic situation, further exposing the Brazilian reality, in which social and structural inequality is evident.

https://doi.org/10.1590/0037-8682-0283-2021

11.

Maternal Mortality in Brazil, 1990 to 2019: a systematic analysis of the Global Burden of Disease Study 2019
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Leal, Lisiane Freitas

; Malta, Deborah Carvalho

; Souza, Maria de Fatima Marinho

; Vasconcelos, Ana Maria Nogales

; Teixeira, Renato Azeredo

; Veloso, Guilherme Augusto

; Lansky, Sônia

; Ribeiro, Antonio Luiz Pinho

; França, Giovanny Vinícius Araújo de

; Naghavi, Mohsen

Revista da Sociedade Brasileira de Medicina Tropical

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2022, Volume 55 Supl. 1 elocation e0279-2021

Resumo: En | Texto: En | PDF: En

Abstract INTRODUCTION Maternal death continues to be one of the most challenging public health problems that needs to be addressed in low and middle-income countries. The objective of this study was to describe the problem of maternal death in Brazil, using estimates from the Global Burden of Disease Study (GBD). METHODS This study used data from the GBD 2019 to show the numbers of deaths and the Maternal Mortality Ratio (MMR) - number of deaths/100,000 live births - in Brazil and its 27 Federated Units (FU), for ages 10 to 54 years, from 1990 to 2019. The annual variation of the MMR was estimated in 1990, 2010, and 2019. The MMR were shown for specific causes as well as for five-year age groups. The estimates were presented with 95% uncertainty intervals (UI). RESULTS The number of maternal deaths, as well as the MMR showed a 49% reduction from 1990 to 2019. This reduction occurred heterogeneously throughout the country, and the profile of the MMR for specific causes changed between 1990 and 2019: from hypertensive gestation diseases, to indirect maternal deaths, followed by hypertensive gestation diseases. In the extreme age groups, the MMR is higher, with mortality increasing exponentially in direct proportion with age. CONCLUSIONS Maternal deaths in Brazil have decreased substantially since 1990; however, the numbers still fall short of what was established by the World Health Organization (WHO). Indirect causes are the greatest problem in more than 60% of the FU, especially for hypertensive pregnancy diseases.

https://doi.org/10.1590/0037-8682-0279-2021

12.

Disease burden in Brazil and its states. Estimates from the Global Burden of Disease Study 2019.
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Malta, Deborah Carvalho

; Passos, Valéria Maria de Azeredo

; Vasconcelos, Ana Maria Nogales

; Carneiro, Mariângela

; Gomes, Crizian Saar

; Ribeiro, Antônio Luiz Pinho

Revista da Sociedade Brasileira de Medicina Tropical

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2022, Volume 55 Supl. 1 elocation e0622-2021

Resumo: En | Texto: En | PDF: En

https://doi.org/10.1590/0037-8682-0622-2021

13.

Experiências de extensão em educação popular em saúde no enfrentamento à pandemia da Covid-19 na Atenção Primária à Saúde
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Souza, Ingrid Gabriele de

; Carvalho, Lais Maria Silva de

; Silva, Felipe Marques da

; Vasconcelos, Ana Claudia Cavalcanti Peixoto de

; Cruz, Pedro José dos Santos Carneiro

Interface - Comunicação, Saúde, Educação

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2022, Volume 26 elocation e210146

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Empenhando-se em abordar a Educação Popular em Saúde (EPS) como ponte universidade-sistema de saúde, este artigo objetiva relatar experiências de extensão universitária realizadas no contexto da Atenção Primária à Saúde (APS) para a contribuição no enfrentamento à pandemia do Covid-19. Teve como caminho metodológico a análise documental e crítica das práticas realizadas por um programa de extensão em EPS de março a dezembro de 2020. Enfocam-se processos formativos mobilizados pelos extensionistas, bem como produção de materiais de apoio à divulgação e ao fortalecimento dos saberes populares em saúde nas mídias sociais. Tais iniciativas deram visibilidade aos saberes e aprendizados oriundos de práticas populares em saúde e ações de EPS na APS. Os espaços educativos possibilitaram o compartilhamento de experiências, bem como o adensamento da formação das pessoas na perspectiva pedagógica da EPS como alternativa de resposta nesse desafiador contexto.

Addressing the Popular Education in Health (PEH) as a link between the university and the health system, this paper aims to report experiences of university extension developed, in the context of Primary Health Care (PHC), to contribute to the fight against the Covid-19 pandemic. The chosen methodology was the documentary type and the critical analysis of practices undertaken by an extension program in PEH from March to December 2020. It focuses on training processes mobilized by extensionists and the production of materials to support the dissemination and strengthening of popular knowledge in health on social media. These initiatives have given visibility to the knowledge and learning of popular health practices and PEH actions in PHC. The educational spaces have enabled the sharing of experiences and deepening the training of people in the pedagogical perspective of PEH as an alternative response in this challenging context.

Con el empeño de abordar la Educación Popular en Salud (EPS) como puente de la universidad–sistema de salud, este artículo tiene el objetivo de relatar experiencias de extensión universitaria realizadas en el contexto de la Atención Primaria de la Salud (APS) para la contribución en el enfrentamiento de la pandemia de covid-19. Tuvo como camino metodológico el análisis documental y crítico de las prácticas realizadas por un programa de extensión en EPS de marzo a diciembre de 2020. Se enfocan en los procesos formativos movilizados por los extensionistas, así como la producción de materiales de apoyo a la divulgación y al fortalecimiento de los saberes populares en salud de las redes sociales. Tales iniciativas dieron visibilidad a los saberes y aprendizajes provenientes de prácticas populares en salud y acciones de EPS en la APS. Los espacios educacionales hicieron posible compartir experiencias, así como adensar en la formación de las personas bajo la perspectiva pedagógica de la EPS como alternativa de respuesta en ese contexto desafiador.

https://doi.org/10.1590/interface.210146

14.

The past, present and future of genomics and bioinformatics: A survey of Brazilian scientists
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Rocha, Mariana

; Massarani, Luisa

; Souza, Sandro José de

; Vasconcelos, Ana Tereza R. de

Genetics and Molecular Biology

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2022, Volume 45 Nº 2 elocation e20210354

Resumo: En | Texto: En | PDF: En

Abstract Brazil has one of the highest rates of scientific production, occupying the ninth position among countries with genome-sequencing projects. Considering the rapid development of this research area and the diversity of professionals involved, the present study aims to understand the expectations, past experiences and the current scenario of Brazilian research in bioinformatics and genomics. The present research was carried out by analyzing the perceptions of 576 researchers in genomics and bioinformatics in Brazil through content and sentiment analysis techniques. This group of participants is equivalent to 48% of the members of the research community. The results suggest that most researchers have a positive perception of the potential of this research area. However, there is concern about the lack of funding for investing in equipment and professional training. As part of a wish list for the future, researchers highlighted the need for higher funding, formal education, and collaboration among research networks. When asked about genomics and bioinformatics in other countries, the participants recognize that sequencing technologies and infrastructure are more accessible, allowing better data volume expansion.

https://doi.org/10.1590/1678-4685-gmb-2021-0354

15.

Does smoking habit affect dendritic cell expression in oral squamous cell carcinoma?
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Barbieri, Silene

; Schuch, Lauren Frenzel

; Cascaes, Andreia Morales

; Gomes, Ana Paula Neutzling

; Tarquinio, Sandra Beatriz Chaves

; Mesquita, Ricardo Alves

; Vasconcelos, Ana Carolina Uchoa

; Etges, Adriana

Brazilian Oral Research

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2022, Volume 36 elocation e044

Resumo: En | Texto: En | PDF: En

Abstract: The aim of this study was to determine the presence of immature CD1a+ and mature CD83+ dendritic cells in oral squamous cell carcinoma, to compare immunoreactivity between smokers and nonsmokers, and to correlate the results with histopathological grading. In this observational study, twenty-eight paraffin-embedded biopsies of oral squamous cell carcinoma were retrospectively retrieved and submitted to immunohistochemistry for immature CD1a+ and mature CD83+. Descriptive and statistical analyses were performed. The sample consisted of 18 man (64.3%) and 10 women (35.7%), with a mean age of 64.6 years in the nonsmoker group and 53.2 years in the smoker group. The tongue (11 cases, 39.2%) was the most commonly affected anatomical site, followed by gingiva (6 cases, 21.4%). Histopathological grading revealed 7 low-grade and 7 high-grade malignancy cases in each group, and no correlation with the number of positive DCs. The number of immature CD1a+ was not significantly different between smoker and nonsmoker groups, while a lower number of mature CD83+ was detected in the smoker group (p = 0.001). Smoking changes the oral immune system and decreases the ability to activate and mature dendritic cells, which may influence the development and progression of oral squamous cell carcinoma.

https://doi.org/10.1590/1807-3107bor-2022.vol36.0044

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